• Cellvizio - an Advancement in Cancer Diagnosis & Treatment

  • Cellvizio® (or probe-based Confocal Laser Endomicroscopy (pCLE)) is a new endoscopic imaging approach that helps improve the diagnosis and management of patients with gastrointestinal and biliary diseases. It is a major advance because it allows physicians to view tissue inside the body at the cellular level during an endoscopy. This is done with a tiny microscope that is threaded through the endoscope.

    These images enable physicians to evaluate suspicious and potentially cancerous tissue and immediately differentiate between normal and abnormal cells, so they can treat the patient immediately and often offer the patient less invasive, targeted treatment options.

    Q. What is endoscopy?

    A. Endoscopy is a medical procedure that involves passing an endoscope - a long, thin, flexible tube with a tiny video camera and light - through an organ in the body to assist in the diagnosis and detection of diseases and disorders. As it passes through, it provides an image of the inside lining of the organ that is transmitted to a video monitor for the physician to view.

    Q. What is Cellvizio?

    A. Cellvizio® is an imaging system that allows doctors to view living tissue inside the body at the cellular level in real time during an endoscopy.

    Studies show that Cellvizio can improve patient care by helping physicians target biopsies and speeding the diagnosis and treatment of a broad range of diseases.

    Q. Why is Cellvizio a major advance in cancer diagnosis and treatment?

    A. Cellvizio allows physicians for the first time to view live tissue inside the body at the cellular level in real-time, while using their regular endoscopes. This means a diagnosis can be made in a less invasive and faster manner than the traditional "blind biopsy + histopathology" method and that physicians can make treatment decisions on the spot.

    Q. What is the proven efficacy of Cellvizio?

    A. A number of clinical trials, including those that supported the registration of the Cellvizio imaging system for use in the digestive and respiratory tracts, have demonstrated the utility of this system for certain key applications in routine clinical practice. In addition, as of mid-2012, over 5,000 Cellvizio procedures have successfully been completed.

    Q. What is a colonoscopy, and how does Cellvizio improve its colon cancer detection benefits?

    A. A colonoscopy is a type of endoscopy that allows a doctor to look inside the colon, also known as the large intestine. It is most often used to look for early signs of cancer in the colon and rectum.

    Cellvizio provides a way for doctors to see pre-cancerous cellular structures in the body during the colonoscopy. It offers a promising imaging approach to reduce the number of biopsies needed and to better differentiate between healthy and potentially cancerous tissue, leading to the early detection of potential cancers

    Q. What is ERCP, and how does Cellvizio improve its ability to diagnose cancers of the bile ducts and pancreas?

    A. ERCP, short for endoscopic retrograde cholangiopancreatography, is an endoscopic procedure that helps detect cancers of the bile ducts and pancreatic cancer, as well as gall stones and other disorders. These cancers are difficult to diagnose, with about a 50 percent failure rate.

    Cellvizio may improve the accuracy of this diagnosis by allowing physicians during ERCP to view dynamic, real-time cellular-level images of biliaro-pancreatic tissues, providing more detailed information on benign and malignant strictures.

    Q. What is Barrett's esophagus, and how is Cellvizio used to better diagnosis it?

    A. Barrett's esophagus is a condition of the esophagus arising from chronic gastroesophageal reflux disease (GERD) that potentially leads to diseases such as esophageal cancer, the fastest growing cancer in the U.S.

    Barrett's esophagus can only be diagnosed by an upper endoscopy procedure that currently involves taking between 8 and as many as 48 biopsies for analysis, but even then cancer cells can be missed.

    Cellvizio may markedly reduce the number of biopsies by allowing the physician to target them more effectively.

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